Dissemination Bottleneck in a Murine Model of Inhalational Anthrax
نویسندگان
چکیده
منابع مشابه
Dissemination bottleneck in a murine model of inhalational anthrax.
Inhalational anthrax is caused by the sporulating bacterium Bacillus anthracis. A current model for progression in mammalian hosts includes inhalation of bacterial spores, phagocytosis of spores in the nasal mucosa-associated lymphoid tissue (NALT) and lungs by macrophages and dendritic cells, trafficking of phagocytes to draining lymph nodes, germination of spores and multiplication of vegetat...
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References 1 Cykert S, Kissling G, Hansen CJ. Patient preferences regarding possible outcomes of lung resection: what outcomes should preoperative evaluations target? Chest 2000; 117: 1551–1559. 2 Ware JE Jr, Sherbourne CD. The MOS 36-items short form health survey (SF36). I. Conceptual framework and item selection. Med Care 1992; 30: 473–483. 3 Cohen J. Statistical Power Analysis for the Behav...
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A recent paper published by Russell et al. suggests that Bacillus anthracis spores can be taken up by lung epithelial cells that then participate in the transport and diffusion of pathogens (6). In a model of BALB/c mice infected by the Sterne strain, the authors focus on data from 2 and 4 h after infection, which limits their analysis to the very early stages of infection. They analyzed spore-...
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Chemokines have been found to exert direct, defensin-like antimicrobial activity in vitro, suggesting that, in addition to orchestrating cellular accumulation and activation, chemokines may contribute directly to the innate host response against infection. No observations have been made, however, demonstrating direct chemokine-mediated promotion of host defense in vivo. Here, we show that the m...
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Results: Of 2499 potentially relevant articles, 73 case reports of pediatric anthrax (5 inhalational cases, 22 gastrointestinal cases, 37 cutaneous cases, 6 cases of primary meningoencephalitis, and 3 atypical cases) met the inclusion criteria. Only 10% of the patients were younger than 2 years, and 24% were girls. Of the few children with inhalational anthrax, none had nonheadache neurologic s...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2012
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00515-12